|Scheme:||Royal Society Research Professorship|
|Dates:||Feb 2006 - Jan 2016|
University of Oxford
my research programme is geared towards determing the strucutre and shape of protein complexes that are difficult to obtain by other methods, in advance of their high resolution structures. To do this we use mass spectrometry and ion mobility . This allows us to piece together protein complexes from their components and to assemble various models for testing. We apply this to very large heterogeneous and dynamic protein complexes since these are the ones that are most difficult to study by other means. Our recent advance with membrane protein complexes are particularly excting since this group of molecules are common drug targets and yet their structures remain elusive. We are hopeful that success in this area will be of high strategic importance for drug discovery since it will open up a new means of studying these intractable targets and assessing their drug binding charactersitics.